Non sedating antihistamines for allergic rhinitis
Both are generally just as effective when it comes to allergic rhinitis symptoms relief but their side effects differ significantly.
So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.Eliminating sedative and cognitive effects is crucial in both children and adults. (30) Consequently, non-sedating antihistamines such as Claritin Kids, are a preferable and safer choice for treating allergic rhinitis and skin itch and hives in children. An essentially non-sedating oral medicinal formulation consisting essentially of: an antihistaminic agent which is limited in both sedating and anticholinergic properties in relation to sedating first-generation antihistamines, an anticholinergic agent, and a nasal decongestant.6.A method of treating allergic rhinitis in a patient suffering therefrom, said method comprising: (i) providing an essentially non-sedating oral medicinal formulation consisting essentially of: (a) an antihistaminic agent limited in both sedating and anticholinergic properties in comparison with sedating first-generation antihistamines, (b) an anticholinergic agent, and (c) a nasal decongestant, and (ii) administering said formulation to said patient in need thereof. Field of the Invention Unrelated to their function of binding to H1 histamine receptors, the first-generation antihistamines produce sedation, an unwanted side effect, but also provide anticholinergic effects, which are helpful for reducing secretions and controlling rhinorrhea.Even given at bedtime, sedating antihistamines' adverse effects may not always have disappeared by the morning.
In contrast to the depressive effects they cause, young children may experience stimulatory effects, such as irritability, excitation, hyperactivity or insomnia.
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Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.
"We're not saying that there's not a difference," says lead researcher Bruce G.
Treatment is most effectively given by an allergist who is certified by the American Board of Allergy and Immunology.